Question 1

In cancer cells you notice that the chromosomes are not shortening,even after many cell divisions.A mutation in the expression of which gene might lead to this observation?

Accepted Answer

A)  DNA-repair genes
B)  retinoblastoma
C)  palladin
D)  telomerase
E)  rasF) C) and D)
G) B) and E) D

Question 2

In an experiment you mutate the retinoblastoma gene RBsuch that its gene product behaves as if hyperphosphorylated.The result would be a ______ association between RB and E2F,with _______ transcription of genes necessary for DNA replication.

Accepted Answer

A)  stronger; unregulated
B)  stronger; tightly regulated
C)  weaker; unregulated
D)  weaker; tightly regulatedE) B) and C)
F) All of the above C

Question 3

Which of the following is true of tumor-suppressor genes?

Accepted Answer

A)  Their normal function is to promote cell proliferation.
B)  Their mutant forms are typically dominant.
C)  They were the first cancer-causing genes to be identified.
D)  None of the above is true of tumor-suppressor genes.E) None of the above
F) C) and D)

Question 4

Considering the clonal evolution of tumors,mutations in which kinds of genes would speed up the rate of mutations?

Accepted Answer

A)  structural genes
B)  metabolism genes
C)  DNA-repair genes
D)  nuclear-import genesE) A) and C)
F) C) and D) C

Exam 15: Cancer Genetics

In cancer cells you notice that the chromosomes are not shortening,even after many cell divisions.A mutation in the expression of which gene might lead to this observation?

Correct Answer
verified
D

In an experiment you mutate the retinoblastoma gene RBsuch that its gene product behaves as if hyperphosphorylated.The result would be a association between RB and E2F,with _ transcription of genes necessary for DNA replication.

Correct Answer
verified
C

Which of the following is true of tumor-suppressor genes?

Correct Answer
verified

Considering the clonal evolution of tumors,mutations in which kinds of genes would speed up the rate of mutations?

Correct Answer
verified
C

Exam 15: Cancer Genetics

In cancer cells you notice that the chromosomes are not shortening,even after many cell divisions.A mutation in the expression of which gene might lead to this observation?

Correct AnswerverifiedD

In an experiment you mutate the retinoblastoma gene RBsuch that its gene product behaves as if hyperphosphorylated.The result would be a ______ association between RB and E2F,with _______ transcription of genes necessary for DNA replication.

Correct AnswerverifiedC

Which of the following is true of tumor-suppressor genes?

Correct AnswerverifiedShow Answer

Considering the clonal evolution of tumors,mutations in which kinds of genes would speed up the rate of mutations?

Correct AnswerverifiedC

Correct Answer
verified
D

In an experiment you mutate the retinoblastoma gene RBsuch that its gene product behaves as if hyperphosphorylated.The result would be a association between RB and E2F,with _ transcription of genes necessary for DNA replication.

Correct Answer
verified
C

Correct Answer
verified

Correct Answer
verified
C