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  -What is the structure indicated by the number 5 in Figure 12.1 and what its functional significance? A)  A band : length of myosin attached to an M line B)  Z line : anchors the thin filaments together C)  M line : where the tails of the myosin molecules are bound to one another D)  sarcomere : the functional unit of muscle contraction whose length is changed as a muscle shortens and lengthens E)  H zone : area of myosin not overlapped by actin -What is the structure indicated by the number 5 in Figure 12.1 and what its functional significance?


A) A band : length of myosin attached to an M line
B) Z line : anchors the thin filaments together
C) M line : where the tails of the myosin molecules are bound to one another
D) sarcomere : the functional unit of muscle contraction whose length is changed as a muscle shortens and lengthens
E) H zone : area of myosin not overlapped by actin

F) B) and C)
G) C) and D)

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Which of the following conditions will result in a skeletal muscle that produces a greater amount of force?


A) more sarcomeres in series
B) fewer sarcomeres in parallel
C) fewer sarcomeres in series
D) fewer myofibrils per muscle cell
E) more sarcomeres in parallel

F) A) and B)
G) A) and C)

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  -What is the structure indicated by the number 2 in Figure 12.1 and what is its functional significance? A)  H zone : area of myosin not overlapped by actin B)  M line : where the tails of the myosin molecules are bound to one another C)  Z line : anchors the thin filaments together D)  sarcomere : the functional unit of muscle contraction whose length is changed as a muscle shortens and lengthens E)  A band : length of myosin attached to an M line -What is the structure indicated by the number 2 in Figure 12.1 and what is its functional significance?


A) H zone : area of myosin not overlapped by actin
B) M line : where the tails of the myosin molecules are bound to one another
C) Z line : anchors the thin filaments together
D) sarcomere : the functional unit of muscle contraction whose length is changed as a muscle shortens and lengthens
E) A band : length of myosin attached to an M line

F) All of the above
G) A) and E)

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Calcium for contraction comes entirely from the sarcoplasmic reticulum in which of the following?


A) smooth muscle only (single -unit or multi -unit)
B) skeletal and smooth muscle only
C) skeletal, smooth, and cardiac muscle
D) skeletal muscle only
E) smooth and cardiac muscle only

F) B) and E)
G) C) and E)

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The velocity at which a skeletal muscle contracts is (directly / inversely) related to load.

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Intercalated disks contain what type of special junctions?


A) tight junctions only
B) gap junctions only
C) hemidesmosomes
D) desmosomes
E) both gap junctions and tight junctions

F) A) and E)
G) B) and E)

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Which of the following appears as dark bands under the microscope?


A) I band
B) A band
C) Z line
D) M line
E) H zone

F) D) and E)
G) B) and E)

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A muscle is stimulated at a frequency that allows the muscle to relax completely between contractions. However, the amount of tension increases with each contraction. What is this called?


A) tetanus
B) treppe
C) twitch
D) recruitment
E) summation

F) None of the above
G) B) and D)

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The sequence of events that links the muscle's action potential to changes in skeletal muscle force development is called what?


A) oxidative phosphorylation
B) crossbridge cycling
C) the sliding -filament model
D) excitation -contraction coupling
E) myoaction coupling

F) C) and E)
G) B) and C)

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Where are gap junctions commonly found?


A) single -unit smooth muscle only
B) multi -unit smooth muscle only
C) cardiac muscle only
D) both single -unit smooth muscle and cardiac muscle
E) both single -unit and multi -unit smooth muscle

F) D) and E)
G) A) and B)

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Calcium is stored in what region of skeletal muscle cells?


A) tropomyosin
B) actin
C) transverse tubule
D) sarcoplasmic reticulum
E) troponin

F) A) and E)
G) C) and D)

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In smooth muscle, calcium triggers contraction by binding to what protein?


A) myosin light chain kinase
B) calmodulin
C) myosin light chain
D) DHP receptors
E) troponin

F) B) and C)
G) B) and D)

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The contractile portion of the thin filament is composed of what protein?


A) myosin
B) troponin
C) actin
D) tropomyosin
E) titin

F) A) and D)
G) C) and D)

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When an action potential is generated within a motor neuron,


A) all of the muscle cells within the motor unit are stimulated to relax.
B) the muscle cells of the motor unit will occasionally contract.
C) only select muscle cells within the motor unit are stimulated to contract.
D) every muscle cell of the motor unit is stimulated to contract.
E) the muscle cells from a neighboring motor unit will contract.

F) A) and E)
G) B) and E)

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Which is the longest phase of a twitch?


A) initial
B) plateau
C) contraction
D) latent
E) relaxation

F) All of the above
G) C) and D)

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Which of the following is the property of skeletal muscle whereby an increase in the frequency of action potentials enhances the force developed by the muscle cell?


A) internal tension
B) external tension
C) length -tension relationship
D) summation
E) force -velocity relationship

F) C) and D)
G) D) and E)

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As the sarcomere length of skeletal muscle is reduced beyond the length where optimum force is developed,


A) the thin filaments overlap one another with myosin bumping into the Z -line, thereby causing the force generated by crossbridges to be exerted on the sarcomere itself rather than transmitted to the ends of the muscle fiber.
B) the amount of calcium released by the sarcoplasmic reticulum is reduced as length increases.
C) the thin filaments are pulled away from one another, thereby reducing their ability to interact with myosin.
D) the thick filaments are pulled away from one another, thereby reducing their ability to interact with actin.
E) the thick filaments overlap one another, thereby reducing their ability to interact with actin.

F) C) and D)
G) A) and D)

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What is the site where a muscle attaches to a stationary bone called?


A) adductor
B) flexor
C) insertion
D) abductor
E) origin

F) A) and E)
G) B) and D)

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Irrespective of an individual muscle cell's ability to regulate the amount of force developed by that cell, the force generated by a skeletal muscle is also controlled at the whole muscle level. Describe the mechanism whereby force of a whole muscle can be modified, including a discussion on motor units.

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In addition to the ability of individual...

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Which of the following transmits action potentials to the interior of the muscle cell to trigger calcium release?


A) motor end plate
B) sarcoplasmic reticulum
C) actin and myosin
D) tendons
E) sarcomeres

F) B) and E)
G) A) and E)

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